NTSR1 anticorps (Extracellular)

N° du produit ABIN7043383

Cet anticorps Lapin Polyclonal détecte spécifiquement NTSR1 dans WB, IHC, IF, FACS, IC et LCI. Il présente une réactivité envers Humain.

Aperçu rapide pour NTSR1 anticorps (Extracellular) (ABIN7043383)

Antigène: NTSR1 (Neurotensin Receptor 1 (High Affinity) (NTSR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NTSR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-NTSR1 anticorps

Épitope: AA 209-224, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Neurotensin Receptor 1

Specificité: 2nd extracellular loop

Réactivité croisée: Humain, Rat

Homologie: rat - 12,16 amino acid residues identical,Mouse - 14

Attributs du produit: Anti-Neurotensin Receptor 1 (extracellular) Antibody (ABIN7043383, ABIN7044767 and ABIN7044768) is a highly specific antibody directed against an epitope of the human NTSR1. The antibody can be used in western blot, immunohistochemistry, live cell imaging, and flow cytometry applications. It has been designed to recognize NTSR1 from human, mouse, and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: EQNRSADGQHAGGLVC corresponding to amino acid residues 209-224 of human NTSR1

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7236125)

Blocking Peptide: (ABIN7236125)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur NTSR1

Antigène: NTSR1 (Neurotensin Receptor 1 (High Affinity) (NTSR1))

Autre désignation: NTSR1

Sujet: NTR1, NTSR1, NTS1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH, NTRR,Neurotensin receptor 1 (NTR1) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR1 and NTR2 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR1 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+ mobilization, although coupling with Gi/o and to Gs has been observed in some expression systems.NTR1 is mainly expressed in the brain and gastrointestinal tract. In the brain, NTR1 mediates body temperature regulation, feeding behavior and locomotion regulation. One of the best studied roles of NTR1 is the regulation of dopamine release suggesting that NTR1 can be a suitable target for the development of a new class of anti-psychotics.2 In the periphery, NTR1 expression has been linked to the control of intestine motility and in the stimulation of growth of the intestine mucosa in both physiological and pathological conditions. NTR1 has been shown to be upregulated in several human cancers where it stimulates tumor growth in response to locally produced neurotensin peptide.3

Alternative names: Neurotensin Receptor 1, NTR1, NTSR1, NTS1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH, NTRR

ID gène: 4923

NCBI Accession: NM_002531

UniProt: P30989