NTSR2 anticorps (C-Term, Intracellular)

N° du produit ABIN7043384

L’anticorps anti-NTSR2 Polyclonal Lapin est utilisé pour la détection de NTSR2 dans des échantillons de Rat. Il a été validé pour WB, IHC, IF et IC.

Aperçu rapide pour NTSR2 anticorps (C-Term, Intracellular) (ABIN7043384)

Antigène: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NTSR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Détail du produit anti-NTSR2 anticorps

Épitope: AA 377-392, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Neurotensin Receptor 2

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Unlikely to recognize human samples.

Homologie: Mouse - 14,16 amino acid residues identical

Attributs du produit: Anti-Neurotensin Receptor 2 Antibody is directed against an epitope at the intracellular C-terminal domain of the rat Neurotensin receptor type 2. Anti-Neurotensin Receptor 2 Antibody (ABIN7043384, ABIN7044769 and ABIN7044770) can be used in western blot, immunohistochemical and immunocytochemical applications, and recognizes NTR2 from rat and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CGEQHSLVPLPQEAPE, corresponding to amino acid residues 377-392 of rat NTSR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: 1:50-1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7236129)

Blocking Peptide: (ABIN7236129)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NTSR2

Antigène: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Autre désignation: NTSR2

Sujet:

Synonyms: NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor

Description: Neurotensin receptor 2 (NTR2) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR2 and NTR1 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR2 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+mobilization. However, the exact signaling mechanisms subsequent to NTR2 activation appear to depend on the species and on the cellular system in which the receptor is studied.NTR2 is expressed mainly in the central nervous system and dorsal root ganglion (DRG) neurons but has been also observed in peripheral tissues such as gastric parietal cells where it probably mediates the neurotensin-induced effects on gastric acid secretion.2The most established physiological role of NTR2 is its role in pain transmission as NTR2-defficient mice showed that NTR2 is the likely mediator of the neurotensin-induced analgesic responses.3

ID gène: 64636

NCBI Accession: NM_012344

UniProt: Q63384