O3FAR1 anticorps (Extracellular, N-Term)

N° du produit ABIN7043397

Cet anticorps anti-O3FAR1 Polyclonal Lapin (ABIN7043397) détecte spécifiquement O3FAR1 dans WB, IHC, FACS et LCI. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour O3FAR1 anticorps (Extracellular, N-Term) (ABIN7043397)

Antigène: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp O3FAR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-O3FAR1 anticorps

Épitope: AA 22-36, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Free Fatty Acid Receptor 4 (GPR120)

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat - identical, human - 14,15 amino acid residues identical

Attributs du produit: Anti-GPR120/FFAR4 (extracellular) Antibody (ABIN7043397, ABIN7044281 and ABIN7044282) is a highly specific antibody directed against an epitope of the mouse Free fatty acid receptor 4. The antibody can be used in western blot and indirect live cell flow cytometry. It has been designed to recognize FFAR4 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RTHFPFFSDVKGDHR, corresponding to amino acid residues 22-36 of mouse FFAR4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1200

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7236163)

Blocking Peptide: (ABIN7236163)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur O3FAR1

Antigène: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Autre désignation: FFAR4

Sujet:

Synonyms: G-protein coupled receptor 120, Free fatty acid receptor 4, FFA4 Receptor, G-protein coupled receptor GT01, Omega-3 fatty acid receptor 1, O3far1

Description: Free fatty acid receptor 4 (FFAR4, GPR120), is a member of the rhodopsin family of 7-transmembrane domain G-protein coupled receptors (GPCRs). GPR120/FFAR4 is activated by long chain fatty acids. The protein is a potential therapeutic target for the treatment of type 2 diabetes mellitus (T2DM). GPR120 is associated to insulin sensitizing, anti-inflammatory, and fat metabolism. Evidence shows that GPR120 may be involved in the development of obesity in mice and humans1-4. GPR120 regulates various physiological processes, including gut hormone secretion, islet function, osteoclastogenesis, anti-inflammation, and adipogenesis2-4.GPR120 binds to omega-3 fatty acids and stabilizes the metabolic homeostasis through a cascade of physiological activities. GPR120 exerts its physiological effects through one of two pathways that involves either Gαq or β-arrestin2,3.GPR120 has been shown to be ubiquitously expressed and is primarily detected in the intestine, adipocytes, and pro-inflammatory macrophages1,2.

ID gène: 107221

NCBI Accession: NM_181745

UniProt: Q7TMA4

Pathways: Hormone Transport