SLC22A3 anticorps (1st Extracellular Loop)

N° du produit ABIN7043416

Cet anticorps Lapin Polyclonal détecte spécifiquement SLC22A3 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour SLC22A3 anticorps (1st Extracellular Loop) (ABIN7043416)

Antigène: SLC22A3 (OCT3) (Organic Cation Transporter 3 (OCT3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC22A3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-SLC22A3 anticorps

Épitope: 1st Extracellular Loop, AA 83-96

Fonction: A Rabbit Polyclonal Antibody to Organic Cation Transporter 3

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Not recommended for human samples.

Homologie: Rat,mouse - 13,14 amino acid residues identical

Attributs du produit: Anti-SLC22A3 (extracellular) Antibody (ABIN7043416, ABIN7044223 and ABIN7044224) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Organic cation transporter 3 from rat and mouse samples. The antibody is unlikely to recognize the protein from human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)ERRGQGH(S)HRYLLE, corresponding to amino acid residues 83-96 of rat OCT3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236191)

Blocking Peptide: (ABIN7236191)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SLC22A3

Antigène: SLC22A3 (OCT3) (Organic Cation Transporter 3 (OCT3))

Autre désignation: SLC22A3

Sujet:

Synonyms: OCT3, Organic cation transporter 3

Description: Organic cation transporter 3 (SLC22A3) belongs to the SLC22A gene family. Organic cation transporters (OCTs) are membrane transport proteins involved in many metabolic processes and detoxification. The transporters are responsible for the uptake and intracellular inactivation of numerous endogenous and exogenous substrates including norepinephrine, epinephrine, dopamine, histamine and serotonin. They are also responsible for the uptake of a variety of anticancer drugs1,2. OCT structure is suggested to have 12 transmembrane domains and a large hydrophobic cleft capable of accommodating a wide variety of chemical species3.In humans, OCT3 is expressed in many tissues, abundantly in the placenta, heart, liver and skeletal muscle. It is also expressed in astrocytes, intestinal epithelium neurons, glia, ependymal cells, and blood-cerebrospinal fluid barrier in choroid plexus epithelial cells. The protein is also widely distributed in the brain. OCT expression is detected in several cancer cell lines and tumor tissue samples1-3.

ID gène: 29504

NCBI Accession: NM_021977

UniProt: O88446