OXGR1 anticorps (C-Term, Intracellular)

N° du produit ABIN7043418

Cet anticorps anti-OXGR1 Polyclonal Lapin (ABIN7043418) détecte spécifiquement OXGR1 dans WB, IF et IHC. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour OXGR1 anticorps (C-Term, Intracellular) (ABIN7043418)

Antigène: OXGR1 (Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OXGR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-OXGR1 anticorps

Épitope: AA 319-332, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Oxoglutarate Receptor 1

Réactivité croisée: Souris, Rat

Homologie: 14 amino acid residues identical,Rat - 12, human - 9

Attributs du produit: Anti-OXGR1/GPR99 Antibody (ABIN7043418, ABIN7044895 and ABIN7044896) is a highly specific antibody directed against an epitope of the mouse Oxoglutarate receptor 1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize OXGR1 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CKASGDLEQGKKDS, corresponding to amino acid residues 319-332 of mouse OXGR1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:600

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236198)

Blocking Peptide: (ABIN7236198)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur OXGR1

Antigène: OXGR1 (Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 (OXGR1))

Autre désignation: OXGR1

Sujet:

Synonyms: Oxoglutarate receptor 1, 2-Oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, aKGR, GPR80, P2RY15, P2Y15

Description: Oxoglutarate receptor 1 (OXGR1) is a receptor for α-ketoglutarate (αKG), a metabolite that is a citric acid cycle intermediate and a glutamine catabolism by-product1. αKG also serves as a metabolic marker and its interaction with OXGR1 has been shown to mediate the adaptive regulation of HCO3- secretion and NaCl reabsorption under acid-base stress3.OXGR1 belongs to the G-protein coupled receptor (GPCRs) protein family. Members of this group contain seven trans-membrane domains and respond to a large variety of ligands and thereby affect key cellular functions that are crucial for cell survival or proliferation2. OXGR1 belongs to a subset of metabolic GPCRs, along with receptors for succinate (GPR91), lactate (GPR81), fatty acids (FFAR) and many more3.OXGR1 is expressed in the kidney3,4 and in the heart, where it affects the contractile function, consistent with the finding that α-ketoglutarate levels are high in heart failure patients5.Because of its major role in maintaining cellular balance and its role in heart contractile activity, identification of molecules that can specifically activate or inhibit this receptor may be very useful in the development of novel therapeutic approach for pathological cardiac hypertrophy5.

ID gène: 239283

NCBI Accession: NM_080818

UniProt: Q6IYF8