Oxytocin Receptor anticorps (Intracellular)

N° du produit ABIN7043419

Cet anticorps Lapin Polyclonal détecte spécifiquement Oxytocin Receptor dans WB, IHC et IF. Il présente une réactivité envers Rat.

Aperçu rapide pour Oxytocin Receptor anticorps (Intracellular) (ABIN7043419)

Antigène: Oxytocin Receptor (OXTR)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oxytocin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: KO Validated

Détail du produit anti-Oxytocin Receptor anticorps

Épitope: AA 346-358, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Oxytocin Receptor

Specificité: Intracellular, C-terminus

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Not recommended for use with human samples.

Homologie: Mouse - identical

Attributs du produit: Anti-Oxytocin Receptor Antibody is directed against an epitope of the rat Oxytocin receptor. Anti-Oxytocin Receptor Antibody (ABIN7043419, ABIN7045341 and ABIN7045342) can be used in western blot analysis. It has been designed to recognize the oxytocin receptor from rat and mouse samples. The antibody is not recommended for use with human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: CSARYLKGSRPGE, corresponding to amino acid residues 346-358 of rat Oxtr

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IP|IHC|ICC

Negative Control: (ABIN7236202)

Blocking Peptide: (ABIN7236202)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur Oxytocin Receptor

Antigène: Oxytocin Receptor (OXTR)

Autre désignation: OXTR

Sujet: OXTR, OT-R, OTR1,Oxytocin receptor belongs to the class 1 family of G-protein coupled receptors (GPCR) and its role is to regulate reproductive physiology, social and emotional behaviors. Like other members belonging to the GPCR superfamily, it has seven transmembrane domains, extracellular N-terminus and intracellular C-terminal tail1,2.The Oxytocin receptor ligand oxytocin, is a peptide that functions both as a hormone and as a neurotransmitter, and plays an important role in social behavior, estrous cycle, induction of labor and milk ejection, anxiety-related behaviors, food intake, stress-related responses, and pain control. Activation of the receptor leads to the stimulation of phospholipase C by interacting with Gαq/11 in response to ligand binding1.Oxytocin receptor is widely abundant in several brain regions including the basal ganglia, the limbic system, the thalamus, the hypothalamus, the brainstem, and the spinal cord. It is also detected in the uterus, mammary gland, ovary, testis, prostate and kidney.Several studies have suggested that administration of oxytocin in humans has the ability to increase generosity, trust and eye gaze. Oxytocin levels in the plasma relates to parent-child bonding behaviors, feelings of romantic love, trust and empathy. Similarly, Oxytocin receptor knockout mice shows several abnormalities in social and emotional behavior such as increased aggression and deficits in nurturing, positive affection, attachment, sensitivity and social memory2,3.

Alternative names: Oxytocin Receptor, OXTR, OT-R, OTR1

ID gène: 25342

NCBI Accession: NM_000916

UniProt: P70536

Pathways: Myometrial Relaxation and Contraction, Feeding Behaviour