P2RX3 anticorps (Intracellular) (Atto 594)

N° du produit ABIN7043421

Cet anticorps anti-P2RX3 est un anticorps Lapin Polyclonal détectant P2RX3 dans IHC et IF. Adapté pour Rat.

Aperçu rapide pour P2RX3 anticorps (Intracellular) (Atto 594) (ABIN7043421)

Antigène: P2RX3 (Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp P2RX3 est conjugé à/à la Atto 594

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-P2RX3 anticorps (Atto 594)

Épitope: AA 383-397, Intracellular

Fonction: A Rabbit Polyclonal Antibody to P2X3 Receptor Conjugated to the Fluorescent Dye ATTO-594

Specificité: Intracellular, C-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - identical, human - 13,15 amino acid residues identical

Attributs du produit: Anti-P2X3 Receptor Antibody (ABIN7043420, ABIN7045090 and ABIN7045091) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect flow cytometry, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize P2X3 receptor from rat, mouse, and human samples. \nAnti-P2X3 Receptor-ATTO Fluor-594 Antibody (ABIN7043421) is directly labeled with an fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The fluorescent label belongs to the class of Rhodamine dyes and can be used with fluorescent equipment typically optimized to detect Texas Red and Alexa-594. Anti-P2X3 Receptor-ATTO Fluor-594 Antibody is especially suited for experiments requiring simultaneous labeling of different markers.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)VEKQSTDSGAYSIGH, corresponding to amino acid residues 383-397 of rat P2X3 receptor 

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: N/A

Commentaires:

Negative Control: (ABIN7236206)

Blocking Peptide: (ABIN7236206)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur P2RX3

Antigène: P2RX3 (Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3))

Autre désignation: P2RX3

Sujet: P2RX3, P2X purinoceptor 3,The P2X3 receptor belongs to the ligand-gated ion channel P2X receptor family, that consists of seven receptor subtypes named P2X1-P2X7 and is activated by extracellular ATP.1,2,3All P2X subunits, with the exception of P2X6, can assemble to form homomeric or heteromeric functional channels.4-5 The different P2X receptors show distinct expression patterns. P2X1-6 has been found in the central and peripheral nervous system, while the P2X7 receptor is predominantly found in cells of the immune system. The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals.6,7 Involvement of ATP in the mechanism of chronic pain has been also suggested.7,8 P2X3 receptor is now becoming a possible target for the development of pain therapeutics.

Alternative names: P2X3 Receptor, P2RX3, P2X purinoceptor 3

ID gène: 81739

NCBI Accession: NM_002559

UniProt: P49654