P2RY2 anticorps (Extracellular) (FITC)

N° du produit ABIN7043425

Cet anticorps Lapin Polyclonal détecte spécifiquement P2RY2 dans FACS et LCI. Il présente une réactivité envers Rat.

Aperçu rapide pour P2RY2 anticorps (Extracellular) (FITC) (ABIN7043425)

Antigène: P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp P2RY2 est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-P2RY2 anticorps (FITC)

Épitope: AA 11-24, Extracellular

Fonction: A Rabbit Polyclonal Antibody to P2Y2 Receptor Conjugated to the Fluorescent Dye FITC

Specificité: Extracellular, C-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat, human - 13,mouse - 14,15 amino acid residues identical

Attributs du produit: Anti-P2Y2 Receptor (extracellular) Antibody (ABIN7043424, ABIN7045138 and ABIN7045139) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize P2RY2 from rat, mouse, and human samples. \nAnti-P2Y2 Receptor (extracellular)-FITC Antibody (ABIN7043424, ABIN7045138 and ABIN7045139)-F) is directly conjugated to fluorescein isothiocyanate (FITC). This labeled antibody can be used in immunofluorescent applications such as direct flow cytometry using live cells.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (CD)TINGTWEGDELGYK, corresponding to amino acid residues 11-24 of rat P2RY2

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: N/A

Commentaires:

Negative Control: (ABIN7582044)

Blocking Peptide: (ABIN7236218)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur P2RY2

Antigène: P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2))

Autre désignation: P2RY2

Sujet: P2Y purinoceptor 2, P2RY2, P2U1,P2Y receptors belong to the G-protein coupled receptor superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiological responses, among them, cardiac function, platelet aggregation and SMC proliferation1.The mammalian P2Y family currently includes eight functional receptors, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y142-4.The P2Y2 receptor is abundantly expressed in the apical membranes of several epithelial tissues including airway5. It has become a leading target for the treatment of cystic fibrosis. Activation of P2RY2 increases Cl- efflux and mucociliary clearance, effects that might relieve symptoms of cystic fibrosis. P2Y2 agonist therapy is tested in an attempt to bypass the dysfunctioning CFTR channel. Several P2Y2 receptor agonists, especially INS37217, being evaluated as possible targets for the treatment of cystic fibrosis6.

Alternative names: P2Y2 Receptor, P2Y purinoceptor 2, P2RY2, P2U1

ID gène: 29597

NCBI Accession: NM_176072

UniProt: P41232

Pathways: Cellular Response to Molecule of Bacterial Origin, Smooth Muscle Cell Migration