KCNK1 anticorps (Extracellular)

N° du produit ABIN7043443

Cet anticorps Lapin Polyclonal détecte spécifiquement KCNK1 dans WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour KCNK1 anticorps (Extracellular) (ABIN7043443)

Antigène: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-KCNK1 anticorps

Épitope: AA 53-69, Extracellular

Fonction: A Rabbit Polyclonal Antibody to KCNK1 Channel

Specificité: Extracellular, near the P1 loop

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse,pig - identical

Attributs du produit: Anti-KCNK1 (extracellular) Antibody is directed against an epitope of the human K2P1.1 channel. Anti-KCNK1  (extracellular) Antibody (ABIN7043443, ABIN7045008 and ABIN7045009) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting KCNK1 in living cells. It has been designed to recognize KCNK1 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human KCNK1 

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200-1:300

Commentaires:

Negative Control: (ABIN7236284)

Blocking Peptide: (ABIN7236284)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur KCNK1

Antigène: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Autre désignation: KCNK1

Sujet: Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1,KCNK1 (also named TWIK-1 or K2P1.1) is a member of the 2-pore (2P) domain K+ channels family that, currently, includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to the classical K+ channel blockers.KCNK1 was the first of the K2P channels to be identified and as its original name indicates (Tandem of P domains in a Weak Inward rectifier K+ channel) the channel behaves as a weak inward rectifier when expressed in heterologous systems. The channel is ubiquitously expressed with the most prominent expression in the brain, kidney and heart.

Alternative names: KCNK1 (TWIK-1), Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1

ID gène: 3775

NCBI Accession: NM_002245

UniProt: O00180