KCNK1 anticorps (Extracellular, P1 Loop)

N° du produit ABIN7886920

Cet anticorps Lapin Polyclonal détecte spécifiquement KCNK1 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour KCNK1 anticorps (Extracellular, P1 Loop) (ABIN7886920)

Antigène: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-KCNK1 anticorps

Épitope: AA 53-69, Extracellular, P1 Loop

Fonction: A Rabbit Polyclonal Antibody to KCNK1 Channel

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse,pig - identical

Attributs du produit: Anti-KCNK1 (extracellular) Antibody is directed against an epitope of the human K2P1.1 channel. Anti-KCNK1  (extracellular) Antibody (ABIN7043443, ABIN7045008 and ABIN7045009) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting KCNK1 in living cells. It has been designed to recognize KCNK1 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human KCNK1 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:300

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236284)

Blocking Peptide: (ABIN7236284)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur KCNK1

Antigène: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Autre désignation: KCNK1

Sujet:

Synonyms: Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1

Description: KCNK1 (also named TWIK-1 or K2P1.1) is a member of the 2-pore (2P) domain K+ channels family that, currently, includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to the classical K+ channel blockers.KCNK1 was the first of the K2P channels to be identified and as its original name indicates (Tandem of P domains in a Weak Inward rectifier K+ channel) the channel behaves as a weak inward rectifier when expressed in heterologous systems. The channel is ubiquitously expressed with the most prominent expression in the brain, kidney and heart.

ID gène: 3775

NCBI Accession: NM_002245

UniProt: O00180