KCNK13 anticorps (1st Extracellular Loop)

N° du produit ABIN7043444

L’anticorps anti-KCNK13 Polyclonal Lapin est utilisé pour la détection de KCNK13 dans des échantillons de Rat. Il a été validé pour WB, IHC, FACS et LCI.

Aperçu rapide pour KCNK13 anticorps (1st Extracellular Loop) (ABIN7043444)

Antigène: KCNK13 (Potassium Channel Subfamily K Member 13 (KCNK13))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNK13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-KCNK13 anticorps

Épitope: 1st Extracellular Loop, AA 54-69

Fonction: A Rabbit Polyclonal Antibody to KCNK13 Channel

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human - 15,16 amino acid residues identical

Attributs du produit: Anti-KCNK13 (extracellular) Antibody is directed against an epitope in the 1st extracellular loop of the rat KCNK13 channel. Anti-KCNK13  (extracellular) Antibody (ABIN7043444, ABIN7045019 and ABIN7045020) can be used in western blot and immunohistochemical applications, and recognizes KCNK13 channel from mouse and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)EERLANFSRGHNLSRE, corresponding to amino acid residues 54-69 of rat KCNK13 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:50-1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236288)

Blocking Peptide: (ABIN7236288)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur KCNK13

Antigène: KCNK13 (Potassium Channel Subfamily K Member 13 (KCNK13))

Autre désignation: KCNK13

Sujet:

Synonyms: Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited K+ channel 1, K2P13.1

Description: KCNK13 (also named Tandem pore domain halotane inhibited K+ channel, THIK -1 or K2P13.1) is a member of the 2-pore (2P) domain K+ channels family that currently includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.1The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. It has been proposed that the functional channel unit is a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH , mechanical stretch, inhalation anesthetics, etc. but are insensitive to classical K+ channel blockers.The KCNK13 channel is activated by arachidonic acid and inhibited by the volatile anesthetic halothane. The channel is relatively widely expressed in peripheral tissues such as kidney, heart, lung and liver but it is also expressed in brain.The physiological function of the KCNK13 channel is not clear but an involvement in the physiological response to reduced oxygen levels (hypoxia) has been proposed.2

ID gène: 64120

NCBI Accession: NM_022054

UniProt: Q9ERS0