SLC29A3 anticorps (Intracellular, N-Term)

N° du produit ABIN7886763

Cet anticorps anti-SLC29A3 Polyclonal Lapin (ABIN7886763) détecte spécifiquement SLC29A3 dans WB. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour SLC29A3 anticorps (Intracellular, N-Term) (ABIN7886763)

Antigène: SLC29A3 (Solute Carrier Family 29 Member 3 (SLC29A3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC29A3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SLC29A3 anticorps

Épitope: AA 37-49, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Equilibrative Nucleoside Transporter 3 (SLC29A3)

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human - 10,13 amino acid residues identical

Attributs du produit: Anti-ENT3 (SLC29A3) Antibody (ABIN7043712, ABIN7044802 and ABIN7044803) is a highly specific antibody directed against an epitope of the rat equilibrative nucleoside transporter 3. The antibody can be used in western blot analysis. It has been designed to recognize ENT3 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DYPAPGLQRPEDR, corresponding to amino acid residues 37-49 of rat ENT3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237052)

Blocking Peptide: (ABIN7237052)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SLC29A3

Antigène: SLC29A3 (Solute Carrier Family 29 Member 3 (SLC29A3))

Autre désignation: SLC29A3

Sujet:

Synonyms: Equilibrative nucleoside transporter 3

Description: Equilibrative nucleoside transporter 3 (ENT3) is responsible for transporting nucleotide synthesis precursors, such as hydrophilic nucleosides and nucleobases within cells1. ENT3 structure includes 11 transmembrane domains and a 51-residue hydrophilic N-terminal region containing two dileucine motifs that are characteristic of endosomal/lysosomal targeting sequences1,2.ENT3 is encoded by the SLC29A3 gene and is expressed in several mouse and human tissues such as placenta, heart, neurons, and astrocytes. In addition, human ENT3 is predominantly expressed in mitochondria in human hepatocytes. Human ENTs are high-capacity transporters, bidirectional, Na+-independent with a wide substrate selectivity1,2. The human ENT family consists of four members: ENT1- ENT4. Nucleoside transport function of ENT3 is maximal at pH 5.5 suggesting that the protein is localized to acidic intracellular compartments, probably lysosomes1,2.Studies show that mutations in human ENT3 can cause various clinical disorders including H syndrome, pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome, lysosomal storage-like disorders and mitochondrial disorders1,2.

ID gène: 353307

NCBI Accession: NM_018344

UniProt: Q80WK7