S1PR1 anticorps (Extracellular, N-Term)

N° du produit ABIN7043771

L’anticorps anti-S1PR1 Polyclonal Lapin est utilisé pour la détection de S1PR1 dans des échantillons de Humain. Il a été validé pour WB, IF, IHC, FACS, LCI et IC.

Aperçu rapide pour S1PR1 anticorps (Extracellular, N-Term) (ABIN7043771)

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI), Immunochromatography (IC)

Détail du produit anti-S1PR1 anticorps

Épitope: AA 17-30, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Sphingosine 1-Phosphate Receptor 1

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,rat - 13,14 amino acid residues identical

Attributs du produit: Anti-S1PR1 (EDG1) (extracellular) Antibody (ABIN7043771, ABIN7045270 and ABIN7045271) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize S1PR1 from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: SDYVNYDIIVRHYN(C), corresponding to amino acid residues 17-30 of human S1PR1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 mg per reaction

ICC: 1:50

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7237267)

Blocking Peptide: (ABIN7237267)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur S1PR1

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Autre désignation: S1PR1

Sujet:

Synonyms: Sphingosine 1-phosphate receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, CD363, CHEDG1

Description: Lysophospholipids constitute a group of important lipid mediators, lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (S1P), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2. Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG), S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3.Sphingosine 1-phosphate receptor 1 (S1PR1) is ubiquitously expressed. S1PR1 mRNA is detected in the brain, heart, spleen, liver, lung, thymus, kidney, skeletal muscle and lymphoid tissues4. Knockout of the gene encoding S1PR1 is lethal and therefore makes in vivo studies difficult5.

ID gène: 1901

NCBI Accession: NM_001400

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2