S1PR2 anticorps (2nd Cytoplasmic Loop)

N° du produit ABIN7043773

Cet anticorps Lapin Polyclonal détecte spécifiquement S1PR2 dans WB et IHC. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour S1PR2 anticorps (2nd Cytoplasmic Loop) (ABIN7043773)

Antigène: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-S1PR2 anticorps

Épitope: 2nd Cytoplasmic Loop, AA 129-146

Fonction: A Rabbit Polyclonal Antibody to Sphingosine 1-Phosphate Receptor 2

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat - 17,18 amino acid residues identical, human - 16

Attributs du produit: Anti-S1PR2 (EDG5) Antibody is directed against an intracellular epitope of mouse sphingosine 1-phosphate receptor 2. Anti-S1PR2 (EDG5) Antibody (ABIN7043773, ABIN7045272 and ABIN7045273) can be used in western blot and immunohistochemistry applications. It has been designed to recognize S1PR2 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: ERQVALAKVKLYGSDKSC, corresponding to amino acid residues 129-146 of mouse S1PR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7237271)

Blocking Peptide: (ABIN7237271)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur S1PR2

Antigène: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Autre désignation: S1PR2

Sujet:

Synonyms: Sphingosine 1-phosphate receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Lysophospholipid receptor B2, LPB2

Description: Lysophospholipids constitute a group of important lipid mediators, lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (S1P), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2.Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG), S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3.Sphingosine 1-phosphate receptor 2 (S1PR2) is ubiquitously expressed. S1PR2 mRNA was detected in the brain, heart, spleen, liver, lung, thymus, kidney and skeletal muscle4. Unlike S1PR1, knockout of SIPR2 gene is not lethal5.

ID gène: 14739

NCBI Accession: NM_004230

UniProt: P52592

Pathways: Synaptic Membrane