SUCNR1 anticorps (Extracellular)

N° du produit ABIN7043783

L’anticorps Lapin Polyclonal anti-SUCNR1 a été validé pour WB, IHC, FACS et LCI. Il convient pour détecter SUCNR1 dans des échantillons de Rat.

Aperçu rapide pour SUCNR1 anticorps (Extracellular) (ABIN7043783)

Antigène: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUCNR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-SUCNR1 anticorps

Épitope: AA 248-262, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Succinate Receptor 1

Specificité: 3rd extracellular loop

Réactivité croisée: Humain, Souris, Rat

Homologie: 15 amino acid residues identical,Mouse - 14, human - 12

Attributs du produit: Anti-GPR91 (SUCNR1) (extracellular) Antibody (ABIN7043783, ABIN7045308 and ABIN7045309) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and live cell flow cytometry. It has been designed to recognize GPR91 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RNVRIASRLDSWPQG, corresponding to amino acid residues 248-262 of rat GPR91/Succinate Receptor 1

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IFC

Negative Control: (ABIN7237300)

Blocking Peptide: (ABIN7237300)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur SUCNR1

Antigène: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Autre désignation: SUCNR1

Sujet: G-protein coupled receptor 91, Succinate receptor 1,GPR91 (Succinate Receptor 1), a member of the GPCR superfamily, is specifically activated by extracellular succinate outside the tricarboxylic acid cycle, resulting in activation of paracrine and endocrine effectors. Activation of GPR91 is associated with several diseases, including hypertension and diabetes1,2.GPR91 was shown to regulate normal retinal vascularization, proliferative ischemic retinopathy and cortical revascularization post-ischemia. Activation of GPR91 influences different tissues such as kidney, heart, retina, white adipose tissue, and liver.Through the activation of GPR91, succinate affects motility, migration, and growth of dendritic cells. In addition, the receptor directly promotes chemotaxis and potentiates activation initiated by Toll-like receptor agonists in dendritic cells1-3.In the heart GPR91 mediates succinate-induced cardiomyocyte death. It was demonstrated that upholding levels of serum succinate can cause cardiac hypertrophy through the activation of the GPR911,2.

Alternative names: GPR91 (SUCNR1), G-protein coupled receptor 91, Succinate receptor 1

ID gène: 408199

NCBI Accession: NM_033050

UniProt: Q6IYF9