TBXA2R anticorps (AA 225-239)

N° du produit ABIN7043809

Cet anticorps Lapin Polyclonal détecte spécifiquement TBXA2R dans WB, IHC et IF. Il présente une réactivité envers Rat.

Aperçu rapide pour TBXA2R anticorps (AA 225-239) (ABIN7043809)

Antigène: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBXA2R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TBXA2R anticorps

Épitope: AA 225-239

Fonction: A Rabbit Polyclonal Antibody to Thromboxane A2 Receptor

Specificité: 3rd intracellular loop

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat - 14,15 amino acid residues identical, human - 12, mouse - 13

Attributs du produit: Anti-Thromboxane A2 Receptor Antibody (ABIN7043809, ABIN7045124 and ABIN7045125) is a highly specific antibody directed against an epitope of the rat TBXA2R. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize TBXA2R from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)HAREATQRPRD(S)EVE, corresponding to amino acid residues 225-239 of rat TBXA2R

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7237385)

Blocking Peptide: (ABIN7237385)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur TBXA2R

Antigène: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Autre désignation: TBXA2R

Sujet: Prostanoid TP receptor, TXA2-R, TBXA2R,Thromboxane A2 (TxA2) is a prostanoid that is synthesized from arachidonic acid and plays an important role in haemostasis, a process regulating platelet aggregation and vascular tone. Thromboxane A2 binds to the thromboxane A2 receptor (TBXA2R) to induce strong vasoconstriction in renal arteries.Thromboxane A2 receptor is a seven-transmembrane G-protein coupled receptor localized on the cell membrane and in intracellular compartments. TBXA2R is expressed in the central nervous system in several types of cells, such as microglia, oligodendrocytes and astrocytes. Imbalances in the levels of the receptor is widely implicated in several cardiovascular, pulmonary, renal and prostate pathologies1-3.Thromboxane A2 receptor mediates vasoconstriction and ischemia and its activation is implicated in atherosclerosis and inflammation. Activation of the receptor induces endothelial cell apoptosis by inhibiting Akt phosphorylation and also inhibits endothelial cell migration and angiogenesis by decreasing Akt and eNOS phosphorylation1-3.

Alternative names: Thromboxane A2 Receptor, Prostanoid TP receptor, TXA2-R, TBXA2R

ID gène: 24816

NCBI Accession: NM_001060

UniProt: P34978