VIPR2 anticorps (Extracellular)

N° du produit ABIN7043877

Cet anticorps anti-VIPR2 est un anticorps Lapin Polyclonal détectant VIPR2 dans WB, IF, FACS, IC et LCI. Adapté pour Humain.

Aperçu rapide pour VIPR2 anticorps (Extracellular) (ABIN7043877)

Antigène: VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VIPR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-VIPR2 anticorps

Épitope: AA 25-37, Extracellular

Fonction: A Rabbit Polyclonal Antibody to VPAC2 Receptor

Specificité: Extracellular, N-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,rat - identical

Attributs du produit: Anti-VPAC2 (VIPR2) (extracellular) Antibody is directed against an extracellular epitope of human VIP and PACAP receptor 2. Anti-VPAC2 (VIPR2) (extracellular) Antibody (ABIN7043877, ABIN7045331 and ABIN7045332) can be used in western blot analysis, immunocytochemistry and indirect flow cytometry applications. It has been designed to recognize VPAC2 from human, rat and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: CRFHLEIQEEETK, corresponding to amino acid residues 25-37 of human VPAC2

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:600

Commentaires:

Cited Application: IFC

Negative Control: (ABIN7237559)

Blocking Peptide: (ABIN7237559)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur VIPR2

Antigène: VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))

Autre désignation: VIPR2

Sujet: VIP and PACAP receptor 2, Vasoactive intestinal polypeptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R3,Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are prominent neuropeptides that are structurally related. Two receptors have similarly high affinity for VIP and PACAP and have therefore been termed VIP and PACAP receptor 1 (VPAC1) and VIP and PACAP receptor 2 (VPAC2). VPAC2 (also known as vasoactive intestinal peptide receptor 2) belongs to the Class II family of G-protein coupled receptors1. A distinct feature of class II GPCRs is the presence of large N-terminal extracellular domains which contain 10 highly conserved amino acids including six cysteines, putative N terminal leader sequences and several potential N-glycosylation sites1.VPAC2 receptor is expressed in the uterus, prostate, smooth muscle of the gastrointestinal tract, seminal vesicles and skin, blood vessels and thymus2. VPAC2 is also expressed in various brain regions including the thalamus and the suprachiasmatic nuclei (SCN)3.VPAC2 plays important roles in the control of mammalian circadian rhythms in the SCN. Mice lacking VPAC2 show altered circadian rhythms in locomotor behavior, neuronal firing and clock gene expression4. Recent studies have also shown that duplication of the VPAC2 gene, and the resulting higher than normal VPAC2 signaling in patients confers a significant risk to schizophrenia5.

Alternative names: VPAC2 (VIPR2), VIP and PACAP receptor 2, Vasoactive intestinal polypeptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R3

ID gène: 7434

NCBI Accession: NM_003382

UniProt: P41587

Pathways: cAMP Metabolic Process