Recombinant LeY anticorps

N° du produit ABIN7072333

Cet anticorps Lapin Chimeric détecte spécifiquement LeY dans ELISA et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant LeY anticorps (ABIN7072333)

Antigène: LeY

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Inconjugué

Application: ELISA, Immunohistochemistry (IHC)

Clone: BR96

Détail du produit

Fonction: Anti-LeY [BR96], Rabbit IgG, kappa

Specificité: The antibody binds Le(Y) with a Ka of 0.1 μM.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG3

Purification: Protein A affinity purified

Immunogène: H3396 cultured line established from a metastasis of a human breast adenocarcinoma.

Isotype: IgG kappa

Information d'application

Indications d'application: The antibody binds specifically to LeY tetrasaccharide, a carbohydrate antigen expressed at the cell surface of selective carcinomas, including those of the colon, breast, ovary and lung. Studies have shown that the monoclonal antibody has toxic effects to antigen-positive tumour cells, performing ADCC at concentrations down to 0.1 μg/mL. The antibody B396 was also shown to perform complement-dependent cytotoxicity at concentrations of 0.1-5.0 μg/mL in certain carcinoma cell lines. The monoclonal antibody also has the ability to be internalised by antigen-positive tumour cells, and can thereby be used to deliver anti-cancer drugs to the specific tumour cells.

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: LeY

Sujet: Lewis Y