Recombinant GPIIb/IIIa anticorps

N° du produit ABIN7072340

L’anticorps Lapin Chimeric anti-GPIIb/IIIa a été validé pour ELISA, IF et WB. Il convient pour détecter GPIIb/IIIa dans des échantillons de Humain.

Aperçu rapide pour Recombinant GPIIb/IIIa anticorps (ABIN7072340)

Antigène: GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp GPIIb/IIIa est non-conjugé

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Clone: 10E5

Détail du produit anti-GPIIb/IIIa anticorps

Fonction: Anti-GPIIb/IIIa [10E5], Rabbit IgG, kappa

Specificité: The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 μg/mL.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: Human blood platelets.

Isotype: IgG kappa

Information d'application

Indications d'application: The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmann's thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa.

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur GPIIb/IIIa

Antigène: GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))

Autre désignation: GPIIb/IIIa

Sujet: Integrin alpha-IIb/beta-3, Glycoprotein IIb/IIIa, αIIbβ3

UniProt: P08514