Recombinant Galanin anticorps (C-Term)

N° du produit ABIN7072341

Cet anticorps anti-Galanin est un anticorps Souris Monoclonal détectant Galanin dans WB, ELISA, ICC et BR. Adapté pour Humain et Souris.

Aperçu rapide pour Recombinant Galanin anticorps (C-Term) (ABIN7072341)

Antigène: Galanin (GAL)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Galanin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Blocking Reagent (BR)

Clone: 4B3

Détail du produit anti-Galanin anticorps

Épitope: C-Term

Fonction: Anti-Galanin [4B3], Mouse IgG1, kappa

Specificité: The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody.

Réactivité croisée: Souris

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: C-terminal fusions of KLH to human galanin,

Isotype: IgG1 kappa

Information d'application

Indications d'application: The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.

Commentaires:

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Galanin

Antigène: Galanin (GAL)

Autre désignation: Galanin

Sujet: Gal peptide

UniProt: P22466

Pathways: Regulation of Hormone Metabolic Process, Feeding Behaviour