Recombinant Integrin beta 7 anticorps

N° du produit ABIN7072355

L’anticorps Lapin Chimeric anti-Integrin beta 7 a été validé pour FACS, IP et BR. Il convient pour détecter Integrin beta 7 dans des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant Integrin beta 7 anticorps (ABIN7072355)

Antigène: Integrin beta 7 (ITGB7)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp Integrin beta 7 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)

Clone: FIB27

Détail du produit anti-Integrin beta 7 anticorps

Fonction: Anti-Integrin beta-7 [FIB27], Rabbit IgG, kappa

Specificité: FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.

Réactivité croisée: Souris

Attributs du produit:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: FIB27 was prepared by immunizing rats with TK1 cells.

Isotype: IgG kappa

Information d'application

Indications d'application: FIB27 can be used for FC, IP and can block TKI cell aggregation and beta-7 intergrin-mediated cell adhesion.

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Integrin beta 7

Antigène: Integrin beta 7 (ITGB7)

Autre désignation: Integrin beta-7

Sujet: FIB-27, FIB 27, Fib-27, Fib27, Fib 27, fib27, fib-27, fib 27, Integrin b7, integrin b-7, ITGB7, Gut homing receptor beta subunit

Pathways: Integrin Complex