Recombinant CD80 (Galiximab Biosimilar) anticorps

N° du produit ABIN7072388

L’anticorps Lapin Chimeric anti-CD80 (Galiximab Biosimilar) a été validé pour BR, ELISA, FACS, IHC, IP et WB. Il convient pour détecter CD80 (Galiximab Biosimilar) dans des échantillons de Humain.

Aperçu rapide pour Recombinant CD80 (Galiximab Biosimilar) anticorps (ABIN7072388)

Antigène: CD80 (Galiximab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp CD80 (Galiximab Biosimilar) est non-conjugé

Application: Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)

Clone: IDEC-114

Détail du produit anti-CD80 (Galiximab Biosimilar) anticorps

Fonction: Anti-CD80 [IDEC-114 (Galiximab)], Rabbit IgG, lambda

Specificité: Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)

Isotype: IgG lambda

Information d'application

Indications d'application: Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximb affects CD28 and CD152 interactions with CD80. This antibody can also be used for FC, WB, ELISA, IP and IHC.

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD80 (Galiximab Biosimilar)

Antigène: CD80 (Galiximab Biosimilar)

Classe de substances: Biosimilar

Sujet: B7-1, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7

UniProt: P33681