Recombinant BTLA anticorps

N° du produit ABIN7072472

L’anticorps Lapin Chimeric anti-BTLA a été validé pour WB, FACS, IP, Func et BP. Il convient pour détecter BTLA dans des échantillons de Souris.

Aperçu rapide pour Recombinant BTLA anticorps (ABIN7072472)

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp BTLA est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func), Blocking Peptide (BP)

Clone: HMBT-6B2

Détail du produit anti-BTLA anticorps

Fonction: Anti-BTLA [HMBT-6B2], Rabbit IgG, kappa

Specificité: This antibody is specific for B and T lymphocyte attenuator (BTLA), which functions as a negative regulator of T cell activation and proliferation, and attenuates B cell proliferation upon associating with its known ligand, herpes virus entry mediator (HVEM).

Attributs du produit:

Original Species of Ab: Hamster, Armenian

Original Format of Ab: IgG

Purification: Protein A affinity purified

Immunogène: This antibody was raised by immunising Armenian hamsters with mouse BTLA:Fc fusion protein.

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody has been used in immunoblot analyses to confirm that B and T lymphocyte attenuator (BTLA) regulates T cell activation through interaction with herpesvirus entry mediator (HVEM) (Sedy et al, 2005), as well as in FACS and yeast display technology to demonstrate that BTLA exhibits structural and expression polymorphisms and is highly induced in anergic CD4+ T Cells (Hurchla et al, 2005). In a mouse conjunctivitis model, treatment with this antibody during the induction phase has been shown to decrease B-cell population, upregulate Th2 cytokine production and increase the conjunctival eosinophile numbers (Ishida et al, 2012). However, treatment with this antibody during the effector phase does not affect the development of experimental conjunctivitis (Ishida et al, 2012).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster IgG format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur BTLA

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Autre désignation: BTLA

Sujet: CD272, B and T lymphocyte attenuator, B- and T-lymphocyte attenuator, B and T lymphocyte associated protein, B- and T-lymphocyte-associated protein, BTLA1, FLJ16065, MGC129743

UniProt: Q7TSA3

Pathways: Cancer Immune Checkpoints