Recombinant SARS-CoV-2 Spike anticorps (C-Term, Extracellular Domain, RBD)

N° du produit ABIN7072712

L’anticorps anti-SARS-CoV-2 Spike Chimeric Souris est utilisé pour la détection de SARS-CoV-2 Spike dans des échantillons de SARS Coronavirus-2 (SARS-CoV-2). Il a été validé pour ELISA, Inh et GCI.

Aperçu rapide pour Recombinant SARS-CoV-2 Spike anticorps (C-Term, Extracellular Domain, RBD) (ABIN7072712)

Antigène: SARS-CoV-2 Spike (SARS-CoV-2 S)

Type d'anticorp: Recombinant Antibody

Reactivité: SARS Coronavirus-2 (SARS-CoV-2)

Hôte: Souris

Clonalité: Chimeric

Conjugué: Cet anticorp SARS-CoV-2 Spike est non-conjugé

Application: ELISA, Inhibition (Inh), Grating Coupled Interferometry (GCI)

Clone: Sb#14

Détail du produit anti-SARS-CoV-2 Spike anticorps

Épitope: C-Term, Extracellular Domain, RBD

Fonction: Anti-Spike protein (RBD) [Sb#14], Mouse IgG1-Fc Fusion,

Specificité:

This antibody recognizes and binds the SARS CoV 2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.

Application Notes original Clone: This antibody is recommended for detection of SARS CoV 2 or 2019-nCoV. Its high specificity to the novel coronavirus SARS-Cov-2 was confirmed via ELISA testing (Walter et al., 2020). Furthermore, grating-coupled interferometry demonstrated that this antibody binds the receptor binding domain (RBD) of the spike protein with high affinity (Walter et al., 2020). Subsequent testing showed that this clone exhibits exceptionally strong inhibition of binding of SARS-Cov-2 RBD to hACE2, which is the receptor for the virus (signal of RBD association with hACE2 decreased over 90 % ) (Walter et al., 2020).

Attributs du produit: This chimeric mouse antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Purification: Purified antibody.

Immunogène: This clone was originally isolated in a form of a synthetic nanobody (sybody) via a 'target swap' selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds.

Isotype: IgG1-Fc Fusion

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Dromedary

OriginalFormat: VHH

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur SARS-CoV-2 Spike

Antigène: SARS-CoV-2 Spike (SARS-CoV-2 S)

Autre désignation: SARS-CoV2 Spike protein

Classe de substances: Viral Protein

Sujet: Receptor Binding Domain, SARS CoV 2 S glycoprotein, Sb45, COVID-19 Spike protein, RBD, Receptor Binding Domain, E2 glycoprotein, E2, Human coronavirus 2 spike glycoprotein, Peplomer protein, S glycoprotein, SARS coronavirus 2 S protein, SARS coronavirus 2 Spike Protein, SARS CoV 2 Spike protein, SARS CoV 2, SARS-CoV-2 S protein, SARSCoV2, SARS-COV-2 S protein, SARS-COV-2 Spike glycoprotein, SARSCOV2 Spike protein, Severe acute respiratory syndrome 2 spike glycoprotein, Severe acute respiratory syndrome virus 2 spike glycoprotein, Spike glycoprotein, 2019-nCoV, SARS-CoV2

UniProt: P0DTC2