WTX anticorps

N° du produit ABIN7073078

Cet anticorps Lapin Polyclonal détecte spécifiquement WTX dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour WTX anticorps (ABIN7073078)

Antigène: WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WTX est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-WTX anticorps

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse FAM123B

Information d'application

Indications d'application: WB (H,M,R) 1: 500-1: 1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur WTX

Antigène: WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))

Autre désignation: FAM123B

Sujet: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.

Poids moléculaire: 125 kDa

ID gène: 72345

NCBI Accession: NP_780388

UniProt: Q7TS75