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B-Cell Linker anticorps

BLNK Reactivité: Souris, Rat IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7073174
  • Antigène Voir toutes B-Cell Linker (BLNK) Anticorps
    B-Cell Linker (BLNK)
    Reactivité
    • 110
    • 74
    • 37
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 112
    • 15
    • 1
    Lapin
    Clonalité
    • 107
    • 21
    Polyclonal
    Conjugué
    • 53
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    Cet anticorp B-Cell Linker est non-conjugé
    Application
    • 111
    • 52
    • 36
    • 26
    • 26
    • 19
    • 17
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Rat
    Purification
    Affinity purification
    Immunogène
    Recombinant protein corresponding to Mouse BLNK
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    Discover our top product BLNK Anticorps primaire
  • Indications d'application
    IHC/IF (M,R) 1:2500-1:5000/1:1500-1:2500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    B-Cell Linker (BLNK)
    Autre désignation
    BLNK (BLNK Produits)
    Synonymes
    anticorps BLNK, anticorps blnk, anticorps MGC147045, anticorps BASH, anticorps Bca, anticorps Ly-57, anticorps Ly57, anticorps Lyw-57, anticorps SLP-65, anticorps AGM4, anticorps BLNK-S, anticorps LY57, anticorps SLP65, anticorps bca, anticorps B-cell linker, anticorps B cell linker, anticorps BLNK, anticorps blnk, anticorps Blnk
    Sujet
    The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
    ID gène
    17060
    NCBI Accession
    NP_032554
    UniProt
    Q9QUN3
    Pathways
    BCR Signaling
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