Cet anticorps Lapin Polyclonal détecte spécifiquement CXCR1 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.
CXCR1 is a chemokine receptor, which is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.