Chloride Channel 5 anticorps

N° du produit ABIN7073471

Cet anticorps Lapin Polyclonal détecte spécifiquement Chloride Channel 5 dans IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Chloride Channel 5 anticorps (ABIN7073471)

Antigène: Chloride Channel 5 (CLCN5)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Chloride Channel 5 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Chloride Channel 5 anticorps

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse ClC-5

Information d'application

Indications d'application: IHC/IF (H,M,R) 1:100-1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Chloride Channel 5

Antigène: Chloride Channel 5 (CLCN5)

Autre désignation: ClC-5

Sujet: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume.Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria.

ID gène: 12728

NCBI Accession: NP_001230691

UniProt: Q9WVD4