EIF2AK1 anticorps

N° du produit ABIN7073875

Détail du produit anti-EIF2AK1 anticorps

Antigène: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF2AK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse Heme-regulated inhibitor

Information d'application

Indications d'application: WB (H,M,R) 1 :500-1: 1000, IHC/IF (M,R) 1:800-1:1600/1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur EIF2AK1

Antigène: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Autre désignation: Heme-regulated inhibitor (EIF2AK1 Produits)

Synonymes: anticorps HCR, anticorps Hri, anticorps HRI, anticorps wu:fj97h09, anticorps zgc:153232, anticorps eukaryotic translation initiation factor 2 alpha kinase 1, anticorps eukaryotic translation initiation factor 2-alpha kinase 1, anticorps eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog, anticorps EIF2AK1, anticorps eif2ak1, anticorps Eif2ak1, anticorps eif2ak1.L

Sujet: The Eif2ak1 Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells, controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.

Poids moléculaire: 70 kDa

ID gène: 15467

NCBI Accession: NP_038585

UniProt: Q9Z2R9

Pathways: Hepatitis C