H2-AB1 anticorps

N° du produit ABIN7074228

L’anticorps anti-H2-AB1 Polyclonal Lapin est utilisé pour la détection de H2-AB1 dans des échantillons de Souris et Rat. Il a été validé pour IF et IHC.

Aperçu rapide pour H2-AB1 anticorps (ABIN7074228)

Antigène: H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp H2-AB1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-H2-AB1 anticorps

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse H2ab1

Information d'application

Indications d'application: IHC/IF (M,R) 1:4000-1:8800

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur H2-AB1

Antigène: H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))

Autre désignation: H2ab1

Sujet: Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells . Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template . Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes . In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes . Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) .

ID gène: 68231

NCBI Accession: NP_080903

UniProt: Q9CQ70