MRPL12
Reactivité: Humain, Souris
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB (M,R) 1: 500-1: 1000, IHC/IF (H) 1:500-1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Antigène
MRPL12
(Mitochondrial Ribosomal Protein L12 (MRPL12))
Autre désignation
MRPL12
Sujet
MRPL12 is a component of the 39S subunit of mammalian mitochondrial ribosomes, and is encoded by a nuclear gene. The protein forms a homodimer, localizes predominantly to mitochondria and binds to the large mitochondrial ribosomal subunit. It is required for CycD/Cdk4- induced cell growth. In addition, forming a ribosomal stalk with MRPL7, MRPL12 is required for the recruitment of translation elongation factors Tu and G to the large ribosomal subunit . It also a part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation and/or ribosome biogenesis during human mitochondrial gene expression.