PGC1 alpha + beta anticorps

N° du produit ABIN7075028

Détail du produit

Antigène: PGC1 alpha + beta

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Réactivité croisée: Souris, Rat

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Human PGC1alpha+beta

Information d'application

Indications d'application: WB (H,M,R) 1: 500-1: 1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détail du antigène

Antigène: PGC1 alpha + beta

Synonymes: anticorps LEM6, anticorps PGC-1(alpha), anticorps PGC-1v, anticorps PGC1, anticorps PGC1A, anticorps PPARGC1, anticorps A830037N07Rik, anticorps ENSMUSG00000079510, anticorps Gm11133, anticorps PGC-1, anticorps Pgc-1alpha, anticorps Pgc1, anticorps Pgco1, anticorps Ppargc1, anticorps PPARG coactivator 1 alpha, anticorps peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, anticorps PPARGC1A, anticorps Ppargc1a

Sujet: PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Poids moléculaire: 91 kDa

ID gène: 19017

NCBI Accession: NP_001317680

UniProt: Q9UBK2