PNN anticorps

N° du produit ABIN7075083

L’anticorps anti-PNN Polyclonal produit chez le Lapin a été validé pour IHC et IF. Il convient pour la détection de PNN dans des échantillons provenant de Humain, Souris et Rat. }

Aperçu rapide pour PNN anticorps (ABIN7075083)

Antigène: PNN (Pinin, Desmosome Associated Protein (PNN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PNN est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-PNN anticorps

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse PNN/DRSP

Information d'application

Indications d'application: IHC/IF (H,M,R) 1:600-1:1200/1:400-1:800

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur PNN

Antigène: PNN (Pinin, Desmosome Associated Protein (PNN))

Autre désignation: PNN/DRSP

Sujet: PNN, also named as DRS or 140 kDa nuclear and cell adhesion-related phosphoprotein, is a 717 amino acid protein, which belongs to the pinin family. PNN localizes in the plasma membrane and is expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. PNN is expressed strongly in melanoma metastasis lesions and advanced primary tumors. PNN as a transcriptional activator binds to the E-box 1 core sequence of the E-cadherin promoter gene. PNN is involved in the establishment and maintenance of epithelia cell-cell adhesion. PNN is a potential tumor suppressor for renal cell carcinoma.

ID gène: 18949

NCBI Accession: NP_032917

UniProt: O35691