TAL1 anticorps

N° du produit ABIN7075819

Cet anticorps anti-TAL1 est un anticorps Lapin Polyclonal détectant TAL1 dans IHC et IF. Adapté pour Rat.

Aperçu rapide pour TAL1 anticorps (ABIN7075819)

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAL1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TAL1 anticorps

Réactivité croisée: Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse Tal1

Information d'application

Indications d'application: IHC/IF (R) 1:800-1:1500/1:400-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TAL1

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Autre désignation: Tal1

Sujet: Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase alpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.

ID gène: 21349

NCBI Accession: NP_001274317

UniProt: P22091

Pathways: Stem Cell Maintenance