TBC1D7 anticorps

N° du produit ABIN7075849

Détail du produit anti-TBC1D7 anticorps

Antigène: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D7 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse TBC1D7

Information d'application

Indications d'application: WB (H,M,R) 1: 500- 1: 1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TBC1D7

Antigène: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Autre désignation: TBC1D7 (TBC1D7 Produits)

Synonymes: anticorps PIG51, anticorps TBC7, anticorps dJ257A7.3, anticorps 2610009C09Rik, anticorps TBC1 domain family member 7, anticorps TBC1 domain family, member 7, anticorps TBC1D7, anticorps Tbc1d7

Sujet: TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.

Poids moléculaire: 36 kDa

ID gène: 67046

NCBI Accession: NP_001239568

UniProt: Q9D0K0