DNMT3A anticorps

N° du produit ABIN7091044

L’anticorps Souris Monoclonal anti-DNMT3A a été validé pour WB. Il convient pour détecter DNMT3A dans des échantillons de Humain.

Aperçu rapide pour DNMT3A anticorps (ABIN7091044)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DNMT3A est non-conjugé

Application: Western Blotting (WB)

Clone: G8L1

Détail du produit anti-DNMT3A anticorps

Homologie: Human

Immunogène: Recombinant human Dnmt3a.

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: Dnmt3a

Sujet:

Synonyms: DNA (cytosine 5 ) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaI, DNA MTase HsaIIIA, DNMT 3a, DNMT, DNMT3A2, M HsaIIIA, M.HsaIIIA, MCMT, Methyl CpG binding domain protein 3a.

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

ID gène: 1788

UniProt: Q9Y6K1