EZH2 anticorps

N° du produit ABIN7091061

Cet anticorps Souris Monoclonal détecte spécifiquement EZH2 dans WB, FACS et IF (cc). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour EZH2 anticorps (ABIN7091061)

Antigène: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EZH2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: E3H5

Détail du produit anti-EZH2 anticorps

Fonction: EZH2 Monoclonal Antibody

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: Recombinant human EZH2.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB(WB(1:500-2000)), FCM(FCM(1 μg/Test)), IF(ICC)(IF(ICC)(1:50-200))

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur EZH2

Antigène: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Autre désignation: EZH2

Sujet:

Synonyms: Enhancer of zeste homolog 2, Enx1h, MGC9169, Enhancer of zeste 2, ENX-1, ENX 1, ENX1, EZH 2, EZH2_HUMAN, Histone-lysine N-methyltransferase EZH2, KMT6A, Lysine N-methyltransferase 6, Enhancer of zeste homolog 2 (Drosophila), Enhancer of zeste, Drosophila, homolog 2, KMT 6,KMT6A, KMT6, WVS2.

Background: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4.

ID gène: 2146

UniProt: Q15910

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation