LIN28B anticorps
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- Antigène Voir toutes LIN28B Anticorps
- LIN28B (Lin-28 Homolog B (LIN28B))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LIN28B est non-conjugé
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Application
- Western Blotting (WB)
- Homologie
- Human
- Immunogène
- Recombinant human LIN28B.
- Clone
- K7L3
- Top Product
- Discover our top product LIN28B Anticorps primaire
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- Indications d'application
- WB 1:300-5000
- Restrictions
- For Research Use only
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- Concentration
- 0.5 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- LIN28B (Lin-28 Homolog B (LIN28B))
- Autre désignation
- LIN28B (LIN28B Produits)
- Synonymes
- anticorps csdd2, anticorps LIN-28, anticorps CSDD2, anticorps 2810403D23Rik, anticorps D030047M17Rik, anticorps Lin-28.2, anticorps lin-28 homolog B, anticorps lin-28 homolog B S homeolog, anticorps lin-28 homolog B (C. elegans), anticorps LIN28B, anticorps lin28b, anticorps lin28b.S, anticorps Lin28b
- Sujet
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Synonyms: Lin-28B, LN28B_HUMAN, CSDD 2, CSDD2, FLJ16517, Lin 28 homolog B (C. elegans), Lin 28.2, Lin-28B, Protein lin-28 homolog B.
Background: Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
- ID gène
- 389421
- UniProt
- Q6ZN17
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