PKD2 anticorps (AA 41-140) (Biotin)

N° du produit ABIN7091533

L’anticorps Lapin Polyclonal anti-PKD2 a été validé pour ELISA et WB. Il convient pour détecter PKD2 dans des échantillons de Humain.

Aperçu rapide pour PKD2 anticorps (AA 41-140) (Biotin) (ABIN7091533)

Antigène: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKD2 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB)

Détail du produit anti-PKD2 anticorps (Biotin)

Épitope: AA 41-140

Réactivité croisée: Humain

Homologie: Mouse,Rat,Cow,Pig,Horse,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Polycystin 2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PKD2

Antigène: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Autre désignation: Polycystin 2

Sujet:

Synonyms: polycystic kidney disease 2, TRPP2, APKD2, C030034P18RIK, MGC138466, MGC138468, PC2, PKD2 (includes EG:5311), PKD4, POLYCISTIN-2, POLYCYSTIN 2, RGD1559992, TRPP2, Polycystic kidney disease 2 protein homolog, PC2.

Background: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.

ID gène: 5311

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity