DNMT3A anticorps (pSer390, pSer393) (HRP)

N° du produit ABIN7091877

Cet anticorps Lapin Polyclonal détecte spécifiquement DNMT3A dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour DNMT3A anticorps (pSer390, pSer393) (HRP) (ABIN7091877)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3A est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA

Détail du produit anti-DNMT3A anticorps (HRP)

Épitope: pSer390, pSer393

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated Synthesised phosphopeptide derived from human Dnmt3a around the phosphorylation site of Ser390 + Ser393

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: Dnmt3a

Sujet:

Synonyms: Dnmt3a (phospho S390 + S393), Dnmt3a (phospho Ser390 + Ser393), p-Dnmt3a (phospho S390 + S393), DNA (cytosine 5) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, DNM3A_HUMAN, DNMT 3a, DNMT, Dnmt3a, DNMT3A2, M.HsaIIIA, MCMT, OTTHUMP00000201149.

Background: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

ID gène: 1788

UniProt: Q9Y6K1