ALKBH7 anticorps

N° du produit ABIN7111484

L’anticorps Lapin Polyclonal anti-ALKBH7 a été validé pour WB, ELISA et IHC. Il convient pour détecter ALKBH7 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ALKBH7 anticorps (ABIN7111484)

Antigène: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ALKBH7 anticorps

Fonction: ALKBH7 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: alkB, alkylation repair homolog 7(E. coli)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ALKBH7

Antigène: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Autre désignation: ALKBH7

Sujet:

Synonyms: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial|Alkylated DNA repair protein alkB homolog 7|Spermatogenesis cell proliferation-related protein|Spermatogenesis-associated protein 11|ALKBH7|ABH7|SPATA11

Background: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110(in vitro), but this activity may be due to the absence of the true substrate(PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death(PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage(PubMed:23666923). Does not display DNA demethylase activity(PubMed:23666923). Involved in fatty acid metabolism(By similarity).

Poids moléculaire: 25 kDa

ID gène: 84266

UniProt: Q9BT30