Ataxin 2 anticorps

N° du produit ABIN7111771

Cet anticorps Lapin Polyclonal détecte spécifiquement Ataxin 2 dans WB, ELISA, IHC, IF et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Ataxin 2 anticorps (ABIN7111771)

Antigène: Ataxin 2 (ATXN2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ataxin 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-Ataxin 2 anticorps

Fonction: ATXN2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ataxin 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:4000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Ataxin 2

Antigène: Ataxin 2 (ATXN2)

Autre désignation: ATXN2

Sujet:

Synonyms: Ataxin-2|Spinocerebellar ataxia type 2 protein|Trinucleotide repeat-containing gene 13 protein|ATXN2|ATX2|SCA2|TNRC13

Background: This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 140-150 kDa

ID gène: 6311

UniProt: Q99700

Pathways: Ribonucleoprotein Complex Subunit Organization