BHLHE22 anticorps

N° du produit ABIN7111942

Cet anticorps Lapin Polyclonal détecte spécifiquement BHLHE22 dans WB, ELISA et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour BHLHE22 anticorps (ABIN7111942)

Antigène: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BHLHE22 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-BHLHE22 anticorps

Fonction: BHLHE22 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: basic helix-loop-helix family, member e22

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur BHLHE22

Antigène: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Autre désignation: BHLHE22

Sujet:

Synonyms: Class E basic helix-loop-helix protein 22 (bHLHe22)|Class B basic helix-loop-helix protein 5 (bHLHb5)|Trinucleotide repeat-containing gene 20 protein|BHLHE22|BHLHB5|TNRC20

Background: Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.

Poids moléculaire: 37 kDa

ID gène: 27319

UniProt: Q8NFJ8