Calsyntenin 1 anticorps

N° du produit ABIN7112234

L’anticorps Lapin Polyclonal anti-Calsyntenin 1 a été validé pour WB et ELISA. Il convient pour détecter Calsyntenin 1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Calsyntenin 1 anticorps (ABIN7112234)

Antigène: Calsyntenin 1 (CLSTN1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calsyntenin 1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Calsyntenin 1 anticorps

Fonction: CLSTN1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: calsyntenin 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Calsyntenin 1

Antigène: Calsyntenin 1 (CLSTN1)

Autre désignation: CLSTN1

Sujet:

Synonyms: Calsyntenin-1|Alcadein-alpha (Alc-alpha)|Alzheimer-related cadherin-like protein|Non-classical cadherin XB31alpha|Soluble Alc-alpha (SAlc-alpha)|CTF1-alpha Alternative names: C-terminal fragment 1-alpha|CLSTN1|CS1|KIAA0911

Background: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment(AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals(By similarity).

Poids moléculaire: 109 kDa

ID gène: 22883

UniProt: O94985