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RAD1 anticorps

RAD1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7112556
  • Antigène Voir toutes RAD1 Anticorps
    RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))
    Reactivité
    • 33
    • 12
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 29
    • 4
    • 1
    Lapin
    Clonalité
    • 32
    • 2
    Polyclonal
    Conjugué
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RAD1 est non-conjugé
    Application
    • 25
    • 17
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    RAD1 homolog(S. pombe)
    Isotype
    IgG
    Top Product
    Discover our top product RAD1 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))
    Autre désignation
    RAD1 (RAD1 Produits)
    Synonymes
    anticorps HRAD1, anticorps REC1, anticorps zgc:56502, anticorps zgc:77779, anticorps RAD1, anticorps xrad1, anticorps DKFZp459H1127, anticorps RAD1 checkpoint DNA exonuclease, anticorps RAD1 homolog (S. pombe), anticorps RAD1, anticorps Rad1, anticorps rad1
    Sujet
    Synonyms:REC1 Background:Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C(RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER). The 9-1-1 complex stimulates DNA polymerase beta(POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I(LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks(DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.
    Poids moléculaire
    32 kDa
    ID gène
    5810
    UniProt
    O60671
    Pathways
    M Phase
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