CEP152 anticorps

N° du produit ABIN7112602

Détail du produit anti-CEP152 anticorps

Antigène: CEP152 (Centrosomal Protein 152kDa (CEP152))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CEP152 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: centrosomal protein 152kDa

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CEP152

Antigène: CEP152 (Centrosomal Protein 152kDa (CEP152))

Autre désignation: CEP152 (CEP152 Produits)

Synonymes: anticorps AI851464, anticorps mKIAA0912, anticorps RGD1305348, anticorps MCPH4, anticorps MCPH9, anticorps SCKL5, anticorps centrosomal protein 152, anticorps CEP152, anticorps Cep152

Sujet: Synonyms:KIAA0912 Background:Necessary for centrosome duplication, the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 Molecules involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615).

Poids moléculaire: 110 kDa

ID gène: 22995

UniProt: O94986

Pathways: M Phase