CHI3L1 anticorps (AA 22-383)

N° du produit ABIN7112692

Cet anticorps Lapin Polyclonal détecte spécifiquement CHI3L1 dans IHC et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CHI3L1 anticorps (AA 22-383) (ABIN7112692)

Antigène: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHI3L1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-CHI3L1 anticorps

Épitope: AA 22-383

Fonction: CHI3L1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 22-383aa

Immunogen: chitinase 3-like 1(cartilage glycoprotein-39)

Isotype: IgG

Information d'application

Indications d'application: IHC: 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CHI3L1

Antigène: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Autre désignation: CHI3L1

Sujet:

Synonyms: Chitinase-3-like protein 1|39 kDa synovial protein|Cartilage glycoprotein 39 (CGP-39, GP-39, hCGP-39)|YKL-40|CHI3L1

Background: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2(Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Poids moléculaire: 43 kDa

ID gène: 1116

UniProt: P36222