CPSF3 anticorps

N° du produit ABIN7112880

Cet anticorps anti-CPSF3 est un anticorps Lapin Polyclonal détectant CPSF3 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CPSF3 anticorps (ABIN7112880)

Antigène: CPSF3 (Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPSF3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CPSF3 anticorps

Fonction: CPSF3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: cleavage and polyadenylation specific factor 3, 73kDa

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CPSF3

Antigène: CPSF3 (Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3))

Autre désignation: CPSF3

Sujet:

Synonyms: Cleavage and polyadenylation specificity factor subunit 3|Cleavage and polyadenylation specificity factor 73 kDa subunit (CPSF 73 kDa subunit)|mRNA 3'-end-processing endonuclease CPSF-73|CPSF3|CPSF73

Background: Component of the cleavage and polyadenylation specificity factor(CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product(DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop(SL) and 5' phosphate on the downstream cleavage product(DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product(DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

Poids moléculaire: 77 kDa

ID gène: 51692

UniProt: Q9UKF6