CPSF3 anticorps

N° du produit ABIN7112880

Détail du produit anti-CPSF3 anticorps

Antigène: CPSF3 (Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPSF3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: cleavage and polyadenylation specific factor 3, 73kDa

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CPSF3

Antigène: CPSF3 (Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3))

Autre désignation: CPSF3 (CPSF3 Produits)

Synonymes: anticorps CPSF3, anticorps si:dkey-81b15.1, anticorps wu:fc32f10, anticorps zgc:101655, anticorps CPSF-73, anticorps CPSF73, anticorps cleavage and polyadenylation specific factor 3, anticorps cleavage and polyadenylation specificity factor subunit 3, anticorps cleavage and polyadenylation specific factor 3 L homeolog, anticorps cleavage and polyadenylation specific factor 3, 73kDa, anticorps cleavage and polyadenylation specificity factor 3, anticorps CPSF3, anticorps cpsf3, anticorps CpipJ_CPIJ011955, anticorps CMU_024380, anticorps PITG_07110, anticorps cpsf3.L, anticorps Cpsf3

Sujet: Synonyms:CPSF73 Background:Component of the cleavage and polyadenylation specificity factor(CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product(DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop(SL) and 5' phosphate on the downstream cleavage product(DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product(DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

Poids moléculaire: 77kd

ID gène: 51692

UniProt: Q9UKF6