EYA1 anticorps

N° du produit ABIN7114028

L’anticorps Lapin Polyclonal anti-EYA1 a été validé pour WB, ELISA, IHC et IF. Il convient pour détecter EYA1 dans des échantillons de Humain et Souris.

Aperçu rapide pour EYA1 anticorps (ABIN7114028)

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-EYA1 anticorps

Fonction: EYA1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: eyes absent homolog 1(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur EYA1

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Autre désignation: EYA1

Sujet:

Synonyms: Eyes absent homolog 1|EYA1

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis(By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues(in vitro)(By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears(By similarity). Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2(By similarity).

Poids moléculaire: 60 kDa,50 kDa

ID gène: 2138

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus